Opiates/Narcotics 

These medications are very helpful for treating RLS. 

but patients can get addicted / tolerance 

generally does not happen if the medications are used to just blunt the majority of the RLS symptoms, 

Intermittent use and drug holidays. 

Constipation, Nausea can also be a significant problem 

Added aspirin and paracetamol have no effect on RLS,

Tramadol 

can be very effective for treating RLS 

Eg for drug holidays from narcotics 

no cross tolerance has developed. aggravation of seizures in patients with a history of fits